The board consists of 35 square 4 by 4 grids of red and blue tiles. Clicking on a grid tile causes a change in the grid's pattern.
 
The goal is to eliminate all of the red tiles so that only blue tiles remain. Each grid is played separately. When you have turned all 35 grids blue, you win the game.
 
There are 8 variants. The rules for how the pattern changes when clicking a tile are different for each variant, but are the same for each grid in the same variant. Part of the puzzle is learning these rules. (See strategy.)
 
The grid in the lower right corner has an 'R' and 'C' tile adjacent to it. Click the 'R' tile to produce a new random pattern for that grid (in case you can't get enough of the puzzles!). Click the 'C' tile to clear the grid to all-blue. You can then create your own patterns by using the standard Zillions editing feature (right-click a tile).